Study shows Vitamin D supplements taken early in life help in the prevention of osteoporosis

Clinical study at Australian Catholic University indicates the benefits of USANA Active Calcium chewables on bone development in females ages nine to 13

“Eat your veggies,” “Don’t run with scissors” and now “Take your calcium and Vitamin D.”

A clinical study conducted at the School of Exercise Science at Australian Catholic University, has shown that taking high quality calcium supplements like USANA’s Active Calcium could help preadolescent girls set the stage for a lifetime of strong, mineral-rich bones. Study results indicated that a supplement containing high quality calcium plus Vitamin D significantly improved bone density, mass and strength in girls ages nine to 13—exactly what experts want to achieve in that time of life to prevent future skeletal issues.

This study is unique because it’s the first randomized, controlled trial to assess bone responses to calcium in twins. Using twins factors out genetic complications that have plagued studies; in working with the Australian Twin Registry, 20 pairs of female twins between the ages of nine and 13 were selected to participate. Scientists administered one twin in each pair a placebo and one twin USANA’s Active Calcium. After six months the study showed significant improvements in bone development in the twin who received the supplement.

“Experts regard osteoporosis as a pediatric disease because the best time to prevent is during childhood and early adolescence,” says Dr. Tim Wood, Executive Vice President of Research and Development at USANA Health Sciences, Inc. “Women put on 50% of their adult bone mineral mass during their teenage years. As such, this is the best time to grow strong, mineral rich bones and the mosteffective way to prevent osteoporosis later in life.” Dr. Wood adds, “We are particularly excited about these findings because they confirm results previously shown in another study conducted in the U.S. at the University of Utah.”

Osteoporosis is a disease in which bones become fragile and more likely to break. If not prevented or if left untreated, osteoporosis can progress painlessly until a bone breaks. While women are four times more likely than men to develop the disease, men also suffer from osteoporosis. It’s important for the body’s bone structure and integrity that bones absorb the right levels of calcium and magnesium, and vitamin D helps this process. USANA’s Active Calcium is a balanced and complete formula of these important ingredients. For a calcium supplement to be effective, it must be absorbable, and USANA’s Active Calcium formula is the outstanding choice among competitors.

Source: Usana Health Sciences

Vitamin D supplementation lowers fracture risk

Researchers have found that doses of 700 to 800 IU of vitamin D3 per day may reduce the risk of hip fracture by 26 percent and nonvertebral fracture by 23 percent.

The May 11 2005 issue of the Journal of the American Medical Association published the results of a meta-analysis of 12 clinical trials involving vitamin D supplementation in the prevention of fracture. The analysis concluded that supplementation with higher than the commonly recommended 400 international unit (IU) doses of vitamin D reduces the risk of hip and nonvertebral fractures in older individuals. The vitamin D studies included a total of 19,114 men and women aged 60 and older. The trials used the form of the vitamin known as cholecalciferol, or vitamin D3, which, according to studies cited in the current review, may be much more effective than the dietary form of the vitamin. The researchers found that doses of 700 to 800 IU of vitamin D3 per day reduced the risk of hip fracture by 26 percent and nonvertebral fracture by 23 percent. Studies that used 400 IU vitamin D3 or less found no significant benefit for either type of fracture. The role of additional calcium supplementation could not clearly be defined from the studies, but it appears that at least 700 milligrams calcium per day may also be necessary for nonvertebral fracture prevention.

Source: Fracture Prevention With Vitamin D Supplementation, Bischoff-Ferrari HA et al, JAMA 2005 May 11;293(18):2257-64.

Magnesium intake increases bone mineral density and may reduce the risk of osteoporosis

Image: U.S. Department of Health and Human Services

A study published in the Journal of the American Geriatric Society has shown that dietary intake of magnesium is associated with an increase in bone mineral density in older men and women.

The study included 2,038 men and women aged 70-79 that were enrolled in the Health, Aging and Body Composition Study. Food frequency questionnaires were used to assess magnesium intakes and document any medications. The data also accounted for variations in age, body mass index (BMI), smoking status, alcohol use, physical activity, estrogen use, and supplemental calcium and vitamin D. Higher magnesium intake through diet and supplements was positively associated with total - body bone mineral density (BMD) in older white men and women. For every 100 mg per day increase in magnesium, there was an approximate 2 per cent increase in whole-body BMD.

The results have important implications since osteoporosis currently affects over 10 million adults in the U.S. alone, with another 34 million suspected to have low bone mass. In addition, earlier dietary surveys have consistently shown that a large portion of adults do not meet the RDA for magnesium.

Source: Magnesium Intake from Food and Supplements Is Associated with Bone Mineral Density in Healthy Older White Subjects , Kathryn M. Ryder MD, MS, Ronald I. Shorr MD, MS, Andrew J. Bush PhD, Stephen B. Kritchevsky PhD, Tamara Harris MD, MPH, Katie Stone PhD, Jane Cauley DrPH, Frances A. Tylavsky DrPH (2005), Journal of the American Geriatrics Society November 2005, Vol 53, No 11, pp 1875-1880

Vitamin D levels inadequate in half of women treated with osteoporosis drugs

Despite efforts to increase knowledge and emphasis on osteoporosis prevention and treatment, research indicates that many women treated for osteoporosis have low levels of vitamin D, a nutrient necessary for adequate bone mineralization.

A recent study involved 1,536 postmenopausal women from 61 study sites who had been taking medications for the treatment of osteoporosis for a minimum of three months. Participants were allowed to have used vitamin D supplements as long as the dosage had remained consistent.Overall, 52 percent of the women had vitamin D levels considered inadequate. Sixty-three percent of women who reported a supplemental intake of 400 IU's or less had inadequate vitamin D levels compared to 45 percent of those whose intake was 400 IU's or greater. Lower levels were also associated with the lack of physician counseling regarding the importance of vitamin D in bone health. The results of this study emphasize the need for greater education of the public and physicians regarding the significance of vitamin D status in the care of postmenopausal women with osteoporosis.

Source: Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy, Holick MF, Siris ES, Binkley N, Beard MK, Khan A, Katzer JT, Petruschke RA, Chen E, de Papp AE, J Clin Endocrinol Metab 2005 Jun;90(6):3215-24