Should I be Taking a Statin Drug to Lower my Cholesterol?

About 2 years ago, a panel of 11 cardiologists met (as reported in USA Today) to lower the recommended level of LDL cholesterol from 130 to 100. Obviously, the pharmaceutical industry was ecstatic with these new recommendations. However, it should not have come as a surprise to them, since 10 of the 11 cardiologists were on the payroll of one of the pharmaceutical companies. The problem with this recommendation is that nearly 98% of the population in the US and Canada has an LDL cholesterol level greater than 100. These recommendations would mean that nearly the entire population should take statin drugs. The New York Times reported that maybe statin drugs should be placed in our drinking water.

Several clinical trials show that individuals who are at risk of developing heart disease can decrease this risk by taking statin drugs. The problem is that researchers are not really sure if it is the lowering of cholesterol that lowers the risk or if it is the anti-inflammatory properties of the statin drugs. I believe that it is probably a combination of both of these effects. If you lower LDL cholesterol, there is just less that is available to become oxidized. Just like aspirin has been shown to decrease the risk of cardiovascular disease due to its anti-inflammatory qualities (it all starts to make sense doesn’t it), the statin drugs do the same. However, I have always believed that we should use drugs as a last resort and not a first choice. Statin drugs are truly over prescribed.

Source: Dr. Strand Health Nuggets (newsletter@Bionutrition.org)

Should I be Taking a Statin Drug to Lower my Cholesterol?

About 2 years ago, a panel of 11 cardiologists met (as reported in USA Today) to lower the recommended level of LDL cholesterol from 130 to 100. Obviously, the pharmaceutical industry was ecstatic with these new recommendations. However, it should not have come as a surprise to them, since 10 of the 11 cardiologists were on the payroll of one of the pharmaceutical companies. The problem with this recommendation is that nearly 98% of the population in the US and Canada has an LDL cholesterol level greater than 100. These recommendations would mean that nearly the entire population should take statin drugs. The New York Times reported that maybe statin drugs should be placed in our drinking water.

Several clinical trials show that individuals who are at risk of developing heart disease can decrease this risk by taking statin drugs. The problem is that researchers are not really sure if it is the lowering of cholesterol that lowers the risk or if it is the anti-inflammatory properties of the statin drugs. I believe that it is probably a combination of both of these effects. If you lower LDL cholesterol, there is just less that is available to become oxidized. Just like aspirin has been shown to decrease the risk of cardiovascular disease due to its anti-inflammatory qualities (it all starts to make sense doesn’t it), the statin drugs do the same. However, I have always believed that we should use drugs as a last resort and not a first choice. Statin drugs are truly over prescribed.

Source: Dr. Strand Health Nuggets (newsletter@Bionutrition.org)

Oxidized or Modified LDL Cholesterol‏

Native or natural LDL cholesterol is not a concern when it comes to heart disease. It acts as a transport vehicle of cholesterol. However, when this LDL cholesterol becomes modified or oxidized by excessive free radicals, it causes a tremendous amount of inflammation of our arteries. Fat soluble antioxidants like vitamin E, beta carotene, and alpha lipoic acid have the ability to incorporate themselves within the wall of the LDL cholesterol and offer protection against this oxidative process. The medical literature shows that the higher the level of antioxidants within the wall of the LDL cholesterol, the more it is able to resist this damage by excessive free radicals. Dr. Daniel Steinberg reported in the New England Journal of Medicine in 1989 that if enough antioxidants were on board, LDL cholesterol levels would not be a concern.

The problem is that physicians are not able to measure “Oxidized” LDL cholesterol levels in the lab. This is primarily research done in clinical trials. Physicians just measure total LDL cholesterol. This is why I believe it is so important to supplement all of these antioxidants and their supporting nutrients at optimal levels (cellular nutrition) to best protect your LDL cholesterol and decrease inflammation of your arteries.

Source: Dr. Strand Health Nuggets (newsletter@Bionutrition.org)

Vitamin D insufficiency common among breast cancer survivors

New research published in the American Journal of Clinical Nutrition showed a correlation between vitamin D levels and various stages of breast cancer development.

Vitamin D influences pathways related to cancer development, but little is currently known about vitamin D status in breast cancer survivors. Recent data taken from the Health, Eating, Activity and Lifestyle (HEAL) study showed a correlation between vitamin D status and breast cancer survivors. Vitamin D concentrations from 790 female breast cancer survivors were obtained and vitamin D insufficiency was found in 597 individuals - or 75% of participants. Average vitamin D concentrations were even lower among African American and Hispanic women.

Controlling for various factors such as body mass index (BMI), race/ethnicity, geography, season, physical activity, diet, and cancer treatments showed that stage of disease independently predicted vitamin D levels.

In this group of breast cancer survivors the prevalence of vitamin D insufficiency was abnormally high. Based on these results, health professionals and clinicians should consider monitoring vitamin D status in breast cancer patients in addition to administering appropriate cancer treatments.

Source: Vitamin D insufficiency in a multiethnic cohort of breast cancer survivors, Neuhouser et al, American Journal of Clinical Nutrition, Vol. 88, No. 1, 133-139, July 2008

What Causes Inflammation of Our Arteries?‏

The first question people should ask themselves is "What actually causes inflammation of my arteries?" If heart disease and aging of my arteries are results of low-grade inflammation over a prolonged period of time, then it would make logical sense to try to avoid those things that cause that inflammation.

Dr. Ross listed several different causes of inflammation of our arteries in his review article found in the New England Journal of Medicine:

· "Oxidized" or "Modified" LDL cholesterol-NOT native LDL cholesterol
· Excessive free radicals created by high blood pressure, diabetes, central obesity, elevated or rapidly rising blood sugars, and from a fatty meal.
· Elevated homocysteine levels (this is a byproduct of protein metabolism that is primarily the result of vitamin B deficiency).
· Elevated levels of insulin due to insulin resistance.

When I treat a patient who has suffered a heart attack or has had coronary by-pass surgery, my goal is to eliminate all the causes of inflammation.

The next several "Health Nuggets" will discuss this health concept.

Source: Dr. Strand Health Nuggets (newsletter@Bionutrition.org)